SB 4.25.34
ihadya santam atmanam
vidama na tatah param
yeneyam nirmita vira
puri saranam atmanah
Translation by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
O great hero, we only know that we are existing in this place. We do not know what will come after. Indeed, we are so foolish that we do not care to understand who has created this beautiful place for our residence.
Purport by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
This lack of Krsna consciousness is called ignorance. In Srimad-Bhagavatam (5.5.5) it is called parabhavas tavad abodha-jatah. Everyone is born ignorant. The Bhagavatam therefore says that we are all born ignorant within this material world. In our ignorance we may create nationalism, philanthropy, internationalism, science, philosophy and so many other things. The basic principle behind all these is ignorance. What then is the value of all this advancement of knowledge if the basic principle is ignorance? Unless a person comes to Krsna consciousness, all of his activities are defeated. This human form of life is especially meant to dissipate ignorance, but without understanding how to dissipate ignorance people are planning and building many things. After death, however, all of this is finished.